Activation of Discs large by aPKC aligns the mitotic spindle to the polarity axis during asymmetric cell division
Asymmetric division generates cellular diversity by producing daughter cells with different fates.In animals, the mitotic spindle aligns with Par complex polarized fate 2 Layers Wooden Plaque determinants, ensuring that fate determinant cortical domains are bisected by the cleavage furrow.Here, we investigate the mechanisms that couple spindle orie